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1.
根据皮肤组织解剖结构特性建立了六层层状模型,并给出了皮肤组织各层的特性参数;考虑了氧合血红蛋白和还原血红蛋白的吸收特性,依据皮肤组织各层的水、血、脂肪、血氧饱和度含量以及血管大小给出了皮肤组织各层的光谱吸收系数;对不同波长散射系数做了适当简化,给出了皮肤组织各层的光谱散射系数。利用蒙特卡罗方法仿真血管组织在收缩与舒张两种状态下, 400~1 000 nm波长光在皮肤组织多层模型中的传输过程,并通过统计大量光子的分布特性,获得了皮肤组织光谱反射系数,并利用模拟所得的两种状态下的反射系数计算得到了光谱容积脉搏波幅度。仿真结果表明,当入射光强一定时,绿光的容积脉搏波幅度优于红光和蓝光。通过计算不同波长光沿皮肤组织深度方向光能流率衰减为1/e时对应的皮肤组织深度,获得了皮肤组织光谱穿透深度。结果显示,血管舒张状态下蓝光和绿光的穿透深度较小,蓝光大部分只能达到表皮层,绿光能到达微循环层,红光可直达真皮层。考虑到光在皮肤组织中传播包含了一个从收缩到舒张的动态过程,基于此,根据穿透深度定义了脉搏波信号产生深度,利用血管舒张与收缩两种不同状态下的穿透深度计算得到了光谱产生深度。结果表明,不同波长光产生深度大于其穿透深度,蓝光产生深度较浅,且其受到的血液吸收调制较小,因而其获得的脉搏信号易受噪声干扰;红光的容积脉搏波产生深度较大,但是相比于绿光其受血液吸收调制较小,且绿光产生深度足够达到真皮血管层,因而红光容积脉搏波的幅度小于绿光。上述仿真结果明确了皮肤组织部分光谱特性,为皮肤组织多光谱容积脉搏波的精确获取及其他相关研究提供了一定的理论基础。 相似文献
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超空泡射弹侵彻问题的实质是特殊水下结构受到高速冲击载荷作用下的动态响应。对12.7 mm口径超空泡射弹侵彻典型水下目标壳体的毁伤效果开展研究,基于LS-DYNA有限元分析软件建立水环境中超空泡射弹垂直侵彻曲面靶板的等效模型,探讨射弹侵彻过程中动能侵彻和气泡溃灭对靶板联合毁伤效果,获得了靶板在各阶段的应力变化和结构变形规律。结果表明:侵彻靶板前,射弹着靶速度为200 m/s时的头部表面水介质压力峰值达768 N,靶板表面有明显下凹变形;侵彻靶板时,伴随着射弹动能侵彻和气泡溃灭冲击,水介质造成的影响不足动能侵彻的2%;侵彻靶板后,在靶板正面形成峰值速度为42 m/s的水射流进一步作用于破口;靶板整体弯曲变形,在200~300 m/s范围内,随着射弹着靶速度的增加,靶板弯曲形变量减小;靶板局部发生延性穿孔,射弹在水环境中具有更好的破口效果,射弹速度变化对破口尺寸影响不大。 相似文献
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We show that the Smith normal form of a skew‐symmetric D ‐optimal design of order is determined by its order. Furthermore, we show that the Smith normal form of such a design can be written explicitly in terms of the order , thereby proving a recent conjecture of Armario. We apply our result to show that certain D ‐optimal designs of order are not equivalent to any skew‐symmetric D ‐optimal design. We also provide a correction to a result in the literature on the Smith normal form of D ‐optimal designs. 相似文献
7.
Nejal M. Bhatt Vijay D. Chavada Mallika Sanyal Pranav S. Shrivastav 《Biomedical chromatography : BMC》2019,33(10)
The present work describes novel methods using densitometry and indirect or off‐line high performance thin‐layer chromatography–mass spectrometry (HPTLC–MS) for the simultaneous detection and quantification of asenapine, propranolol and telmisartan and their phase II glucuronide metabolites. After chromatographic separation of the drugs and their metabolites the analytes were scraped, extracted in methanol and concentrated prior to mass spectrometric analysis. Different combinations of toluene and methanol–ethanol–n‐butanol–iso‐propanol were tested for analyte separation and the best results were obtained using toluene–methanol–ammonia (6.9:3.0:0.1, v/v/v) as the elution solvent. All of the drug–metabolite pairs were separated with a homologous retardation factor difference of ≥22. The conventional densitometric approach was also studied and the method performances were compared. Both of the approaches were validated following the International Conference on Harmonization guidelines, and applied to spiked human plasma samples. The major advantage of the TLC–MS approach is that it can provide much lower limits of detection (1.98–5.83 pg/band) and limit of quantitation (5.97–17.63 pg/band) with good precision (?3.0% coefficient of variation) compared with TLC–densitometry. The proposed indirect HPTLC–MS method is simple yet effective and has tremendous potential in the separation and quantitation of drugs and their metabolites from biological samples, especially for clinical studies. 相似文献
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Chiral separability of boron cluster species studied by screening approaches utilizing polysaccharide‐based chiral stationary phases 下载免费PDF全文
In this study, the screening steps of chiral separation strategies with polysaccharide‐based chiral stationary phases were applied on boron cluster compounds in normal‐phase liquid chromatography (NPLC) and polar organic solvents chromatography (POSC). Since the screening steps were initially developed to analyze organic compounds, their applicability for boron clusters was investigated. Overall, the screening steps in NPLC were applicable for the separation of zwitterions, while for anions mostly no elution was observed. A hypothesis for the latter behavior is precipitation of anions in the nonpolar mobile phases. Ten out of 11 compounds could be partially or baseline separated on the NPLC screening systems. In POSC, all zwitterions were separated on at least one of the screening systems, with an overall lower retention as in NPLC. Anions were detected but not separated in the majority of the experiments. Also their retention on the chiral stationary phases was very limited. This study showed that the chiral discrimination potential of chemically modified polysaccharides is meaningful for chiral separations of structurally chiral boron cluster species, but needs further systematic research, in which recognition mechanisms should be further explored. In addition, some unusual peaks also indicated that conditions with a high separation efficiency must first be searched for some of the tested systems. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
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Jairo Z. Goncalves 《代数通讯》2017,45(12):5193-5201
Let k(t) be the field of rational functions over the field k, let σ be a k-automorphism of K = k(t), let D = K(X;σ) be the ring of fractions of the skew polynomial ring K[X;σ], and let D? be the multiplicative group of D. We show that if N is a noncentral normal subgroup of D?, then N contains a free subgroup. We also prove that when k is algebraically closed and σ has infinite order, there exists a specialization from D to a quaternion algebra. This allows us to explicitly present free subgroups in D?. 相似文献